Primary Sjögren’s syndrome and B-non-Hodgkin lymphoma: role of CD4+ T lymphocytopenia
Identifieur interne : 001360 ( Main/Exploration ); précédent : 001359; suivant : 001361Primary Sjögren’s syndrome and B-non-Hodgkin lymphoma: role of CD4+ T lymphocytopenia
Auteurs : Faten Ismail [Égypte] ; Amel Mahmoud [Égypte] ; Hisham Abdelhaleem [Égypte] ; Amro Mamdoh [Égypte] ; M. Geneidy [Égypte] ; Enas Kamal [Égypte]Source :
- Rheumatology International [ 0172-8172 ] ; 2013-04-01.
English descriptors
Abstract
Abstract: Primary Sjögren’s syndrome (PSS) is associated with increased risk of lymphoproliferative malignancy, and B-cell non-Hodgkin lymphoma (B-NHL) is the most frequent type. To evaluate CD4+ T lymphocytes distributions in patients with (PSS) and the association of CD4+ T lymphocytopenia with the development of (B-NHL), this study included 8 (PSS) patients associated with B-NHL (group I), 50 (pSS) patients without B-NHL (group II), and 30 healthy volunteers who served as controls. The frequency of circulating CD4+ and CD8+ T lymphocytes distributions and CD4+/CD8+ T cell ratio was assessed using flow cytometry coulter EPICS-XL and compared between patients groups and controls. There was statistically significant CD4+ T lymphocytopenia in (PSS) patients with B-NHL than those without lymphoma and controls (P = 0.001). Moreover, a significant low CD4+/CD8+ T cell ratio 0.8 in group I than group II and controls (P = 0.001) was found. Significant positive correlations of CD4+ T lymphocytopenia with other risk factors (parotid swelling, vasculitis, rheumatoid factors, low complement, cryoglobulinemia) were detected. CD4+ T lymphocytopenia is associated with B-NHL developed in patients with PSS and can be considered as an important predictor of lymphoma.
Url:
DOI: 10.1007/s00296-012-2464-7
Affiliations:
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Geneidy</name><affiliation wicri:level="1"><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Ophthalmology, Faculty of Medicine, EL-Minia University, EL-Minia</wicri:regionArea><wicri:noRegion>EL-Minia</wicri:noRegion></affiliation></author><author><name sortKey="Kamal, Enas" sort="Kamal, Enas" uniqKey="Kamal E" first="Enas" last="Kamal">Enas Kamal</name><affiliation wicri:level="1"><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Tropical Medicine, Faculty of Medicine, EL-Minia University, EL-Minia</wicri:regionArea><wicri:noRegion>EL-Minia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology International</title><title level="j" type="sub">Clinical and Experimental Investigations</title><title level="j" type="abbrev">Rheumatol Int</title><idno type="ISSN">0172-8172</idno><idno type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2013-04-01">2013-04-01</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1021">1021</biblScope><biblScope unit="page" to="1025">1025</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD4+ lymphocytopenia</term><term>Non-Hodgkin lymphoma</term><term>Sjögren’s syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Primary Sjögren’s syndrome (PSS) is associated with increased risk of lymphoproliferative malignancy, and B-cell non-Hodgkin lymphoma (B-NHL) is the most frequent type. To evaluate CD4+ T lymphocytes distributions in patients with (PSS) and the association of CD4+ T lymphocytopenia with the development of (B-NHL), this study included 8 (PSS) patients associated with B-NHL (group I), 50 (pSS) patients without B-NHL (group II), and 30 healthy volunteers who served as controls. The frequency of circulating CD4+ and CD8+ T lymphocytes distributions and CD4+/CD8+ T cell ratio was assessed using flow cytometry coulter EPICS-XL and compared between patients groups and controls. There was statistically significant CD4+ T lymphocytopenia in (PSS) patients with B-NHL than those without lymphoma and controls (P = 0.001). Moreover, a significant low CD4+/CD8+ T cell ratio 0.8 in group I than group II and controls (P = 0.001) was found. Significant positive correlations of CD4+ T lymphocytopenia with other risk factors (parotid swelling, vasculitis, rheumatoid factors, low complement, cryoglobulinemia) were detected. CD4+ T lymphocytopenia is associated with B-NHL developed in patients with PSS and can be considered as an important predictor of lymphoma.</div></front></TEI><affiliations><list><country><li>Égypte</li></country></list><tree><country name="Égypte"><noRegion><name sortKey="Ismail, Faten" sort="Ismail, Faten" uniqKey="Ismail F" first="Faten" last="Ismail">Faten Ismail</name></noRegion><name sortKey="Abdelhaleem, Hisham" sort="Abdelhaleem, Hisham" uniqKey="Abdelhaleem H" first="Hisham" last="Abdelhaleem">Hisham Abdelhaleem</name><name sortKey="Geneidy, M" sort="Geneidy, M" uniqKey="Geneidy M" first="M." last="Geneidy">M. Geneidy</name><name sortKey="Kamal, Enas" sort="Kamal, Enas" uniqKey="Kamal E" first="Enas" last="Kamal">Enas Kamal</name><name sortKey="Mahmoud, Amel" sort="Mahmoud, Amel" uniqKey="Mahmoud A" first="Amel" last="Mahmoud">Amel Mahmoud</name><name sortKey="Mamdoh, Amro" sort="Mamdoh, Amro" uniqKey="Mamdoh A" first="Amro" last="Mamdoh">Amro Mamdoh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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